All research in which data are to be collected through the cooperation of a hospital or other institution/agency must have the approval of that institution. IRB approval does not connote institutional access. The policies and procedures of any research performance site should be discussed with the advisory committee chair prior to approaching anyone at the institution. Many institutions have their own human subjects committees that must approve the study before institutional approval for access to subjects is granted. These committees cannot be utilized in place of a UNC-Chapel Hill IRB, but as noted in the previous section, the UNC-Chapel Hill IRB may facilitate an agreement with other IRBs so only an approval from one of the IRBs is needed. At times an external IRB will not be willing to review a study until it has approval from a UNC-Chapel Hill IRB.