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jia-rong-wu

Jia-Rong Wu, PhD, RN, MSN

Assistant Professor

Phone: (919) 966-8057
Email: jiarongw@email.unc.edu
Specialty Area: Adult Health, Cardiovascular Nursing, Family-Focused Intervention, Health Disparities, Health Literacy, Heart Failure, Medical Surgical Nursing, Medication Adherence, Outcomes Research, Self-Care Behaviors

The University of North Carolina at Chapel Hill
School of Nursing
Carrington Hall, CB #7460
Chapel Hill, NC 27599-7460

Office: 435

Jia-Rong Wu PhD, RN is an Assistant Professor in the School of Nursing. She is a nurse researcher whose research interests include medication adherence, health disparities, and psychosocial and environmental factors that influence medication adherence and health-related outcomes in patients with heart failure. She has a PhD from the University of Kentucky and a MSN in adult nurse specialist from the University of Pennsylvania.

In my doctoral program, I verified the importance of medication adherence on outcomes by using the Medication Event Monitoring System (MEMS), an objective measure of adherence that is generally acknowledged to be “the best” measure of medication adherence in research settings. And I also used mixed methods to identify predictors of medication adherence and barriers to adherence that need to be targeted in educational counseling interventions to improve medication adherence in patients with HF. During my post-doctoral fellowship, I worked closely with nurse scientists in the RICH (Research and Intervention for Cardiovascular Health) Heart Program, a highly successful and productive research collaborative dedicated to mentorship and cardiovascular research. In addition, I served as a co-investigator and principal investigator (PI) for the successful completion of a number of studies funded by American Heart Association (AHA) and the American Association of Critical-care Nurses (AACN). Building on the findings about the effects of medication adherence from my doctoral studies, I then developed and tested a theory-based, MEMS-feedback intervention to improve medication adherence in patients with HF. The intervention did significantly improve medication adherence and health outcomes although the intervention effect was not sustained after the intervention was complete. Currently, I am working with two interdisciplinary research teams (one HF research team and one hypertension research team) whose members are involved in research on management of HF and hypertension using a variety of approaches that include self-care strategies, health literacy, improving medication adherence, reducing health disparities, and manipulating psychosocial and environmental factors that influence medication adherence and outcomes in patients with HF and hypertension.

I am experienced in conducting intervention studies in patients with heart failure, most recently in a pilot study of the FamLit intervention (K23NR014489), which is an outgrowth of the earlier theory-based, MEMS-feedback intervention. We included a family member and used educational materials at an appropriate literacy level and found that the FamLit intervention did improve medication adherence during the intervention and the intervention effect was significantly sustained 3 months after the intervention was complete. Patients in the FamLit intervention group also had a longer time to first cardiac event although the differences did not reach statistical significance due to shorter-term follow-up, limited cardiac events, and small sample size. The results of that pilot study provide the basis for the proposed R01 which will involve further efficacy testing of the FamLit over a longer period of time and will include relevant health outcomes (i.e., hospitalization and death) as well.

Fellow of American Heart Association (2015)

American Heart Association Marie Cowan Promising Young Investigator Award (2009)

Southern Nursing Research Society D. Jean Wood Nursing Research Award recipient (2009)

American Heart Association Martha Hill New Investigator Award finalist (2007)

Heart Failure Society of American Nursing Research Award finalist (2007)

American Association of Heart Failure Nurses finalist (2007)

Selected Publications

Lekavich, C., Barksdale, D. J., Neelon, V. J., & Wu, J.R. (in press). Heart Failure Preserved Ejection Fraction (HFpEF): An Integrated and Strategic Review. Heart Failure Reviews.

Cummings, D.M., Wu, J.R., Cene, C., Halladay, J., Donahue, K.E. Hinderliter, A., Bosworth, H., Miller, C., Garcia, B., Tillman, J., & DeWalt, D.A. (in press). Predictors of Inadequate Medication Adherence in the Rural South. Journal of Rural Health.

Shah, D., Simms, K., Barksdale, D.J., & Wu, J.R. (in press). Improving medication adherence for patients with chronic heart failure: Challenges and solutions. Journal of Research Reports in Clinical Cardiology.

Wu, J. R., Lennie, T.A., Frazier, S.K., & Moser, D.K. (in press). Health-related quality of life, functional status and cardiac event-free survival in patients with heart failure. Journal of Cardiovascular Nursing. PMID: 25774841

Wu, J. R., Song, E. K., & Moser, D. K. (2015). Type D Personality, Self-Efficacy, and Medication Adherence in Patients with Heart Failure—A mediation analysis. Heart & Lung, 44, 276-281. PMID: 25979573, PMCID: PMC4470745

Cené, C.W., Haymore, L., Lin F., Laux, J., Jones, C.D., Wu, J.R., DeWalt, D.A., Pignone, M., & Corbie-Smith, G. (2015). Family Member Accompaniment to Routine Medical Visits is Associated with Better Self-Care in Heart Failure Patients. Chronic Illness, 11, 21-32. PMID: 24740555

Lee, K.S., Lennie, T.A., Wu, J.R., Biddle, M., & Moser, D.K. (2014). Depressive symptoms, health-related quality of life, and cardiac event-free survival in patients with heart failure: A mediation analysis. Quality of Life Research, 23, 1869-76. PMID: 24488573

Moser, D.K., Lee, K. S., Wu, J.R., Mudd-Martin, G., Jaarsma, T., Huang, T.Y., Fan, X.Z., Stromberg, A., Lennie, T.A., & Riegel, B. (2014). Identification of symptom clusters among patients with heart failure: An international observational Study. International Journal of Nursing Studies, 51, 1366-72. PMID: 24636665

Wu, J.R. & Moser, D.K. (2014). Type D personality predicts poor medication adherence in patients with heart failure. International Journal of Behavioral Medicine, 21, 833-42. PMID: 24198039

Dekker, R.L., Lennie, T.A., Doering, L.V., Chung, M.L., Wu, J.R., & Moser, D.K., (2014). Coexisting anxiety and depressive symptoms in patients with heart failure. European Journal of Cardiovascular Nursing, 13, 168-76. PMID: 24408885, PMCID: PMC3992982

Dekker, R.L., Moser, D.K., Tovar, E.G., Chung, M.L., Heo, S., Wu, J.R., Dunbar, S.B., Pressler, S.J.,&  Lennie, T.A. (2014). Depressive symptoms and inflammatory biomarkers in patients with heart failure. European Journal of Cardiovascular Nursing, 13, 444-50. PMID: 24062026, PMCID: PMC3994172

Wu, J.R., DeWalt, D.A., Baker, D.W., Schillinger, D., Ruo, B., Bibbins-Domingo, K., Macabasco-O’Connell, A., Holmes, G.M., Broucksou, K.A., Erman, B., Hawk, V., Cene, C.W., DeLong Jones, C., & Pignone, M. (2014). A single-item self-report medication adherence question predicts hospitalization and death in patients with heart failure. Journal of Clinical Nursing, 13, 2554-64. PMID: 24355060, PMCID: PMC4065236

Jones, C.D., Holmes, G.M., DeWalt, D.A., Erman, B., Wu, J.R., Hawk, V., Cené, C.W., Broucksou, K., Baker, D.W., Schillinger, M.D., Ruo, B., Bibbins-Domingo, K., Macabasco-O’Connell, A., Pignone, M. (2014). Self-reported recall and daily diary-recorded measures of weight monitoring adherence: associations with heart failure-related hospitalization. BMC Cardiovascular Disorders, 31, 14:12. PMID: 24483776

Wu, J.R., Holmes, G.M., DeWalt, D.A., Macabasco-O’Connell, A., Bibbins-Domingo, K., Ruo, B., Baker, D.W., Schillinger, D., Weinberger, M., Broucksou, K.A., Erman, B., Jones, C.D., Cene, C.W., & Pignone, M. (2013). Low literacy is associated with increased risk of hospitalization and death among individuals with heart failure. Journal of General Internal Medicine, 28, 1174-1180. PMID: 23478997

 Wu, J.R., Lennie, T.A., Dekker, R.L., Biddle, M., & Moser, D.K. (2013). Medication adherence, depressive symptoms, and cardiac event-free survival in patients with heart failure. Journal of Cardiac Failure, 19, 317-324. PMID: 23663814

Cené, C.W., Haymore, L.B., Dolan-Soto, D., Lin, F.C., Pignone, M., DeWalt, D.A., Wu, J.R., Jones, C. D. (2013). Self-care confidence mediates the association between perceived social support and self-care maintenance in adults with heart failure. Journal of Cardiac Failure,19, 202-210. PMID: 23482082

Wu, J.R., Frazier, S.K., Rayens, M.K., Lennie, T.A., Chung, M.L., & Moser, D.K. (2013). Medication adherence, social support, and event-Free survival in patients with heart failure. Health Psychology, 32, 637-646. PMID: 22746258

Eastwood, J.A., Moser, D.K., Riegel, B.J., Albert, N.M., Pressler, S., Chung, M.L., Dunbar, S., Wu, J.R., & Lennie, T.A. (2012). Commonalities and differences in correlates of depressive symptoms in men and women with heart failure. European Journal of Cardiovascular Nursing, 11, 356-365. PMID: 22414584

Jones, C.D., Holmes, G.M., Dewalt, D.A., Erman, B., Broucksou, K., Hawk, V., Cene, C.W., Wu, J.R., & Pignone, M. (2012). Is adherence to weight monitoring or weight-based diuretic self-adjustment associated with fewer heart failure-related emergency department visits or hospitalizations? Journal of Cardiac Failure, 18, 576-584. PMID: 22748492

Dewalt, D.A., Schillinger, D., Ruo, B., Bibbins-Domingo, K., Baker, D.W., Holmes, G.M., Weinberger, M., Macabasco-O'Connell, A., Broucksou, K., Hawk, V., Grady, K. L., Erman, B., Sueta, C.A., Chang, P.P., Cene, C.W., Wu, J.R., Jones, C.D., & Pignone, M. (2012). Multisite randomized trial of a single-session versus multisession literacy-sensitive self-care intervention for patients with heart failure. Circulation, 125, 2854-62. PMID: 22572916

Wu, J.R., Lennie, T.A., Chung, M.L., Frazier, S.K., Dekker, R.L., Biddle, M.J., & Moser, D.K. (2012). Medication adherence mediates the relationship between marital status and cardiac event-free survival in patients with heart failure. Heart & Lung, 41, 107-114. PMID: 22054720

 Wu, J.R., Corley, D.J., Lennie, T.A., & Moser, D.K. (2012). Effect of a medication-taking behavior feedback, theory-based intervention on outcomes in patients with heart failure. Journal of Cardiac Failure, 18, 1-9. PMID: 22196835

Dekker, R.L., Lennie, T.A., Albert, N.M., Rayens, M.K., Chung, M.L., Wu, J.R., Song, E.K., & Moser, D.K. (2011). Depressive symptom trajectory predicts one-year health-related quality of life in patients with heart failure. Journal of Cardiac Failure, 17, 755-763. PMID: 21872146

Chung, M.L., Lennie, T.A., Dekker, R.L., Wu, J.R., & Moser, D.K. (2011). Depressive symptoms and poor social support have a synergistic effect on event-free survival in patient with heart failure. Heart & Lung, 40, 492-501. PMID: 21453972

De Jong, M.J., Chung, M. L., Wu, J.R., Riegel, B., Rayens, M.K., & Moser, D.K. (2011). Linkages between anxiety and outcomes in heart failure. Heart & Lung, 40, 393-404. PMID: 21453974

 Wu, J.R., Moser, D.K., Riegel, B., McKinley, S., & Doering, L.V. (2011). Impact of pre-hospital delay in seeking medical treatment on in-hospital complications after acute myocardial infarction. Journal of Cardiovascular Nursing, 26, 184-193.

Lennie, T.A., Song, E.K., Wu, J.R., Chung, M.L., Dunbar, S.B., Pressler, S.J., & Moser, D.K. (2011). Three gram sodium intake is associated with longer event-free survival only in patients with advanced heart failure. Journal of Cardiac Failure, 17, 325-330.

Wu, J. R., Moser, D. K., De Jong, M., Rayens, M. K., Riegel, B., Chung, M., & Lennie, T. A. (2010). Rurality and event-free survival in patients with heart failure. Heart & Lung, 39, 512-520. PMCID: PMC3039282

Lee, K. S., Lennie, T.A., Riegel, B., Heo, S., Wu, J. R., Chung, M. L., Rayens, M. K., & Moser, D.K. (2010) Symptom clusters in women and men with heart failure and their impact on cardiac event-free survival. Journal of Cardiovascular Nursing, 25, 263-272.

Wu, J. R., Lennie, T. A., De Jong, M., Frazier, S. K., Heo, S., Chung, M. L., & Moser, D.K. (2010). Medication adherence is a mediator of the relationship between ethnicity and event-free survival in patients with heart failure. Journal of Cardiac Failure, 16, 142-149.

Chung, M. L., Lennie, T. A., Riegel, B., Wu, J. R., Dekker, R. L., & Moser, D. K. (2009). Marital status is an independent predictor of event-free survival of patients with heart failure. American Journal of Critical Care, 18, 562-570.

Riegel, B., Driscoll, A., Suwanno, J., Moser, D. K., Lennie, T. A., Chung, M. L., Wu, J. R., Dickson, V.V., Carlson, B., & Cameron, J. (2009). Heart failure self-care in developed and developing countries. Journal of Cardiac Failure, 15, 508-516.

Wu, J. R., Moser, D. K., Lennie, T .A., De Jong, M., Rayens, M. K., Chung, M. L., & Riegel, B. (2009). Defining an evidence-based cutpoint for medication adherence in heart failure. American Heart Journal, 157, 285-291.

Wu, J. R., Moser, D. K., Chung, M. L., & Lennie, T .A. (2008). Objectively measured, but not self-reported, medication adherence independently predicts event-free survival in patients with heart failure. Journal of Cardiac Failure, 14, 203-210.

Wu, J. R., Moser, D. K., Chung, M., & Lennie, T.A. (2008). Predictors of medication adherence using a multidimensional adherence model in patients with heart failure. Journal of Cardiac Failure, 14, 603-614.

Wu, J. R., Chung, M., Lennie, T. A. Hall, L. A., & Moser, D.K. (2008). Testing the psychometric properties of the medication adherence scale in patients with heart failure. Heart & Lung, 37, 334-343.

Wu, J. R., Moser, D. K., Lennie, T. A., Peden, A., Chen, Y. C., & Heo, S. (2008). Factors influencing medication adherence in patients with heart failure. Heart & Lung, 37, 8-16.

Wu, J. R., Moser, D. K., Lennie, T. A., & Burkhart, P. V. (2008). Medication adherence in patients with heart failure --- A review of the literature. Nursing Clinics of North America, 43, 133-153.

Chung, M. L., Lennie, T. A., De Jong, M., Wu, J. R., Riegel, B., & Moser, D. K. (2008) Patients differ in their ability to self-monitor adherence to low sodium diet vs. medication. Journal of Cardiac Failure, 14, 114-120.

Chen, C. H., Wu, J. R., Yen, M., & Chen, Z. C. (2007). A model of medication taking behavior in elderly individuals with chronic disease. Journal of Cardiovascular Nursing, 22, 359-365.