Associate Professor & Director, Biobehavioral Laboratory
The University of North Carolina at Chapel Hill
School of Nursing
Carrington Hall, CB #7460
Chapel Hill, NC 27599-7460
Dr. Silveyra is the Director of the Biobehavioral Laboratory in the UNC School of Nursing. Her research focuses on sex differences in inflammatory lung disease. She studies the role of sex hormones and steroid hormone receptor signaling in mechanisms of lung inflammation. Her expertise includes animal models of asthma and air pollution exposure, rodent endocrine models of gonadectomy/hormone replacement/estrous cycle regulation, and transgenic models of sex steroid hormone receptors. She also has expertise in biomarker research, employing transcriptomics and miRNA profiling to clinical studies of bronchopulmonary dysplasia and pulmonary hypertension of the newborn. Her work has been funded by multiple foundation grants and the National Institutes of Health. She currently holds K01 and R03 awards from the National Heart, Lung and Blood Institute.
Dr. Silveyra received her bachelor’s and master’s degrees in Molecular Biology and Biotechnology, and her Ph.D. in Biochemistry from the University of Buenos Aires, Argentina. She trained as a postdoctoral fellow at Penn State College of Medicine, focusing on mechanisms of pulmonary surfactant protein expression with Dr. Joanna Floros, after being selected as an Ambassadorial Scholar of The Rotary Foundation. She joined the Penn State faculty in 2011 as Research Associate, and as Assistant Professor and NIH K12 BIRCWH scholar in 2013. She was promoted to Associate Professor in 2018, prior to joining UNC in September 2018.
Dr. Silveyra is a mentor and advocate for women and underrepresented minority trainees, and she serves in various national organizations and committees, including the American Physiological Society, the American Thoracic Society, the Organization for the Study of Sex Differences, and the Society for the Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) where she is Treasurer-elect and member of the Board of Directors. She is also a member and co-chair of the inaugural National Academies of Sciences “New Voices” program.
|2018||New Voices in Sciences, Engineering and Medicine (SEM) inaugural cohort, National Academies of Sciences|
|2018||American Physiological Society (APS) Respiration Section New Investigator Award|
|2018||Sex and Gender Health Education Summit Travel Award|
|2017||Penn State College of Medicine “Distinguished Early Stage Investigator Award”|
|2017||Penn State College of Medicine Inspired Together Community Award|
|2017||Harrell Health Science Library READ Poster Recognition Award|
|2017||SACNAS – HHMI Advanced Leadership Institute|
|2017||APS Dale J. Benos Early Career Professional Service Award|
|2017||APS Respiration Section Outstanding Trainee Award|
|2017||“All In at Penn State: An Achievement Award for Commitment to Diversity and Inclusion”|
|2017||The Extra Mile Award, Leadership Harrisburg Area|
|2017||OSSD-BSD prize for best paper published in Biology of Sex Differences in 2016|
|2016||Latina Leadership Award|
|2016||Linton-Poodry SACNAS Summer Leadership Institute|
|2016||Hershey Rotary Club Community Service Award|
|2016||YWCA “Tribute to Women of Excellence” Award|
|2015||Gordon Research Conference “Lung Development, Injury and Repair” Travel Award|
|2015||NHLBI Programs to Increase Diversity in Health-Related Research (PRIDE). Scholar of the “Functional and Applied Genomics of Blood Disorders” 2015-2017 cohort.|
|2015||NIDDK Network of Minority Health Research Investigators (NMRI) Travel Award|
|2014||Society for the Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) Travel Award|
|2014||FASEB/MARC Travel Award for the American Physiological Society (APS) Professional Skills Training Course|
|2014||Penn State Commission for Women Faculty “Achieving Women Award”|
|2014||Paul Harris Fellow Award, The Rotary Foundation, Rotary International|
|2013||Carl Storm Underrepresented Minority Fellowship. Gordon Research Conference on “Lung Development, Injury and Repair”|
|2012||American Thoracic Society Minority Trainee Travel Award|
|2011||Bond and Bradley Outstanding Postdoctoral Award|
|2009||American Society for Cell Biology Postdoctoral Travel Award|
|2008||The Rotary Foundation Academic-Year Ambassadorial Scholarship|
|2007||Summa cum laude Doctoral Thesis dissertation|
|2007||Argentinean Physiological Society Student Travel Award|
|2006||Argentinean Society for Clinical Investigation Travel Award|
|2005||Argentinean Society for Clinical Investigation Travel Award|
|2004||Argentinean Society for Clinical Investigation Travel Award|
|2004||Argentinean National Research Council Doctoral scholarship|
|2003||Argentinean Agency for the Promotion of Science and Technology Doctoral scholarship|
BIBLIOGRAPHY AND PRODUCTS OF SCHOLARSHIP:
Books and Chapters
- Chapter 5: ”Ozone Exposure and Human Disorders” In “Environmental Toxicology” by Silveyra, P, Fuentes N, Rivera L. Edited by Felix D’Mello. CAB International, UK. In press.
- Chapter 3: “Estrogen receptor signaling mechanisms”. In “Intracellular Signalling Proteins”, Vol 116, 1st Edition. Advances in Protein Chemistry and Structural Biology (APCSB) series, Elsevier. Edited by R. Donev. ISBN 9780128155615. Available online Feb 4, 2019. https://doi.org/10.1016/bs.apcsb.2019.01.001.
- Chapter 1: “Understanding the Intersection of Environmental Pollution, Pneumonia, and Inflammation: Does Gender Play a Role?”: In “Contemporary Topics of Pneumonia” by Silveyra, P, Fuentes N, Rivera L. Edited by Zissis C. Chroneos. InTechOpen Books, Croatia. ISBN 978-953-51-3708-5, Print ISBN 978-953-51-3707-8, Published: December 20, 2017; DOI: 10.5772/66055
- Chapter 9: “Developmental Lung Disease”. In “Gender, Sex Hormones and Respiratory Disease: A Comprehensive Guide”, by Silveyra, P. Edited by Anna R. Hemnes. Humana Press ©2016. ISBN 978-3-319-23996-5. DOI: 10.1007/978-3-319-23998-9.
- Diccionario Multilingüe de Criminalística (Multilingual Criminalistics Dictionary), by Machado Schiaffino, CA. Buenos Aires; La Rocca ©2008. ISBN 978-987-517-119-0
- “Sistemas de Identificación Humana” (Human Identification Systems), by Silveyra J and Silveyra, P. Buenos Aires; La Rocca ©2006. ISBN: 9789875170933 (book co-author).
- Chapter 10: “Biochemical Forensic Systems for Human Identification”, Silveyra, P. In “La Escena del Crimen” (The Crime Scene), by Silveyra J. Buenos Aires; La Rocca ©2003. ISBN: 9789875170605.
(*data-based; †publication with student; ‡senior author)
- Fesen K, Silveyra P, Fuentes N, Nicoleau M, Rivera L, Kitch D, Graff G, Siddaiah R. Exhaled Breath Condensate microRNA Expression Associated with Chronic Pseudomonas Infection in Cystic Fibrosis. Under Revision. *†
- Fuentes N, Nicoleau M, Cabello N, Chroneos Z, Silveyra P. 17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-dependent manner. Under revision. *†‡
- Naeem A, Silveyra P. Sex differences in pediatric and adult asthma. European Medical Journal. In press. EMJ Respir. ‡
- Naeem A, Ahmed I, Silveyra P. Bronchopulmonary Dysplasia: An Update on Experimental Therapeutics. EMJ. 2019;4:20-29. Editor’s pick ‡
- Fuentes N, Cabello N, Nicoleau M, Chroneos Z, Silveyra P. Modulation of the lung inflammatory response to ozone by the estrous cycle. Physiol Rep. 2019 Mar;7(5):e14026. doi: 10.14814/phy2.14026.*†‡
- Fuentes N, Silveyra P. Lung MicroRNA Profiling Across the Estrous Cycle in Ozone-Exposed Mice. J. Vis. Exp. (143), e58664, doi:10.3791/58664 (2019).*†‡
- Fuentes N, Silveyra P. Endocrine control of lung function and inflammation. Exp Biol Med. 2018 Dec 3; 243(17-18):1313-1322. https://doi.org/10.1177/1535370218816653.†‡
- Vargas-Pelaez AF, Ramirez SI, Valdes-Sanchez C, Piedra-Abusharar S, Romeu J, Carmichael C, Bascoy S, Baron R, Pichardo-Lowden A, Albarracin N, Jones C, Silveyra P. Implementing a Medical Interpreter Training Program as a Strategy to Developing Humanism. BMC Med Educ. 2018 Jun 18;18(1):141. doi: 10.1186/s12909-018-1254-7.*†‡
- Fuentes N, Roy A, Mishra V, Cabello N, Silveyra P. Sex-specific microRNA expression networks in an acute model of ozone-induced lung inflammation. Biol Sex Differ. 2018 May 8;9(1):18. doi: 10.1186/s13293-018-0177-7.*†‡
- Silveyra GR, Silveyra P, Vatnick I, Medesani DA, Rodriguez EM. Effects of atrazine on vitellogenesis, steroid levels, and oxidative stress in female red swamp crayfish Procambarus clarkii. Aquat Toxicol. 2018 Feb;197:136-142. doi: 10.1016/j.aquatox.2018.02.017. Epub 2018 Feb 21.*†
- Halstead ES, Umstead T, Davies M, Kawasawa YI, Silveyra P, Howrylak JA, Yang L, Guo W, Hu S, Kurundu Hewage E, Myers R, Cooper TK, and Chroneos ZC. GM-CSF overexpression after lethal influenza A virus infection prevents mortality by blocking M1-like airway monocyte/macrophage polarization. Respir Res. 2018 Jan 5;19(1):3. doi: 10.1186/s12931-017-0708-5.*
- Silveyra P, Zeldin DC. It all begins in utero: cord blood bacterial DNA and T-cell immunity. Am J Respir Cell Mol Biol. 2017 Oct;57(4):379-380. doi: 10.1165/rcmb.2017-0185ED.
- Mishra V, Banga J, Silveyra P. Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets. Pharmacol Ther. 2017 Aug 23. pii: S0163-7258(17)30221-8. doi: 10.1016/j.pharmthera.2017.08.011.‡
- Fino K, Yang L, Silveyra P, Hu S, Umstead TM, DiAngelo S, Halstead ES, Cooper TK, Abraham T, Takahashi Y, Zhou Z, Wang HG, and Chroneos ZC. SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection. Sci Rep. 2017 Aug 4;7(1):7262. doi: 10.1038/s41598-017-07724-5.*
- Carney M, Tarasiuk A, DiAngelo S, Silveyra P, Podany A, Birch L, Paul I, Kelleher S, Hicks S. Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery. PediatrRes. 2017 Apr 19. doi: 10.1038/pr.2017.54.*†
- Rivera L, Siddaiah R, Oji-Mmuo C, Silveyra G, Silveyra P. Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant. Front. Pediatr., 31 March 2016, 4:33. doi: 10.3389/fped.2016.00033.‡
- Mishra V, DiAngelo S, Silveyra P. Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation. Biol Sex Differ. 2016 Mar 5;7:16. doi:10.1186/s13293-016-0069-7.*‡
- Cabello N, Mishra V, Sinha U, DiAngelo S, Chroneos ZC, Ekpa NA, Cooper TK, Caruso, CR, Silveyra P. Sex differences in the expression of lung inflammatory mediators in response to ozone. Am JPhysiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1150-63. doi: 10.1152/ajplung.00018.2015. Epub 2015 Sep 4.*†‡
- Yang L, Carrillo M, Wu Y, DiAngelo S, Silveyra P, Umstead TM, Halstead SE, Davis M, Hu S, Floros J, McCormack FX, Chroneos ZC. SP-R210 (Myo18A) variants as intrinsic modulators of macrophage priming and activation. PLoS One. 2015 May 12;10(5):e0126576.*
- Tsotakos N, Silveyra P, Lin Z, Thomas NJ, Vaid M, Floros J. Regulation of translation by upstream translation initiation codons of surfactant protein A (SP-A1) splice variants. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L58-75.*
- Grageda M, Silveyra P, Thomas NJ, DiAngelo S, Floros J. DNA Methylation Profile and Expression of Surfactant Protein A2 gene in Lung Cancer. Exp Lung Res. 2014 Dec 16.*
- Silveyra P, Chroneos ZC, Thomas NJ, DiAngelo S, Howrylak, J, Noutsios G, Tsotakos N, Umstead TM, Floros J. Knockdown of Drosha in human alveolar type II cells alters expression of Surfactant Protein A in culture: a pilot study. Exp Lung Res. 2014 Sep;40(7):354-66.*
- Silveyra P, DiAngelo S, Floros J. An 11-nt sequence polymorphism at the 3’UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. Am J Physiol Lung Cell Mol Physiol 2014 Jul 1;307(1):L106-19.*
- Olmeda B, Umstead TM, Silveyra P, Pascual A, López-Barneo J, Phelps DS, Floros J, Pérez-Gil J. Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response. J Proteomics. 2014 Apr 14;101:179-91.*
- Silveyra P, Floros J. Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. Gene. 2013 Dec 1;531(2):126-32.
- Phelps DS, Umstead TM, Silveyra P, Hu S, Wang G, Floros J. Differences in the alveolar macrophage proteome in transgenic mice expressing human SP-A1 and SP-A2. Journal of Proteomics and Genomics Research 2013, Vol. 1, issue 2, pp2-26.*
- Noutsios GT, Silveyra P, Bhatti, F, Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences interacts with 14-3-3; role of cis elements and secondary structure. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L722-35.*
- Yang W, Ni L, Silveyra P, Singh A, Noutsios G, Wang G, DiAngelo S, Sanusi O, Raval M, Floros J. Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing. J Mol Biochem. 2013 Feb 20;2(1):40-55.*
- Silveyra P, Floros J. Air Pollution and Epigenetics: Effects on SP-A and Innate Host Defense in the Lung. Swiss Med Wkly. 2012 May 2;142:w13579.
- Durrani F, Phelps DS, Weisz J, Silveyra P, Hu S, Mikerov AN, Floros J. Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice and phagocytosis after Klebsiella pneumoniae infection. Exp Lung Res. 2012 May;38(4):165-72.*
- Silveyra P, Floros J. Genetic variant associations of human SFTPA1, SFTPA2, and SFTPD with acute and chronic lung injury. Front Biosci (Landmark Ed). 2012 Jan 1;17:407-29.
- Floros J, Londono D, Gordon D, Silveyra P, DiAngelo S, Viscardi, R Worthen G, Shenberger J, Wang G, Lin Z, Thomas NJ. IL18R1 and IL18RAP SNPs may associate with Bronchopulmonary Dysplasia in African American infants. Pediatr Res. 2012 Jan;71(1):107-14.*
- Silveyra P, Raval M, Simmons B, DiAngelo S, Wang G, Floros J. The Untranslated Exon B of Human Surfactant Protein A2 (SFTPA2) mRNAs is an Enhancer for Transcription and Translation.Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L795-803.*
- Silveyra P, Wang G, Floros J. Human SP-A1 (SFTPA1) variant-specific 3′UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. Am J Physiol Lung Cell Mol Physiol. 2010 Oct;299(4):L523-34.*
- Silveyra P, Cataldi N, Lux-Lantos VAR, Libertun C. Role of orexins in the hypothalamic-pituitary-ovarian relationships. Acta Physiol (Oxf). 2010 Mar;198(3):355-60.
- Silveyra P, Cataldi N, Lux-Lantos VAR, Libertun C. Gonadal steroids modulated hypocretin/orexin type-1 receptor expression in a brain region, sex and daytime specific manner. Regul Pept. 2009 Nov 27;158(1-3):121-6.*
- Garcia-Tornadu IA, Diaz-Torga GS, Risso G, Silveyra P, Cataldi N, Ramirez MC, Low MJ, Libertun C, Becu-Villalobos D. Hypothalamic orexin, OX1, α-MSH and MCRs expression in dopaminergic D2R knockout mice. Neuropeptides. 2009 Aug;43(4):267-74.*
- Wang G, Guo X, Silveyra P, Kimball S, Floros J. Cap-independent translation of human SP-A 5’-UTR variants; A double-loop structure and cis-element contribution. Am J Physiol Lung Cell MolPhysiol. 2009 Apr;296(4):L635-47.*
- Silveyra P, Lux-Lantos VAR, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle. Effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E977-85.*
- Silveyra P, Catalano PN, Lux-Lantos VAR, Libertun C. Impact of the Proestrous Milieu on Expression of Orexin Receptors and Prepro-Orexin in Rat Hypothalamus and Hypophysis. Actions ofCetrorelix and Nembutal. Am J Physiol Endocrinol Metab.2007 Mar;292(3):E820-8.*
- Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VAR. GABAB1 Knock-Out Mice Reveal Alterations In Prolactin Levels, Gonadotropic Axis and Reproductive Function. Neuroendocrinology. 2005;82(5-6):294-305.*
- Bianchi MS, Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VAR. Effect of Androgens on Sexual Differentiation of Pituitary Gamma-Aminobutyric Acid Receptor Subunit GABA (B) Expression. Neuroendocrinology. 2004;80(3):129-42.*
Refereed other products of scholarship
- Mishra V, Banga J, Silveyra P. Pharmacological approaches targeting immune cell and oxidative biology in allergic asthma. Atlas of Science, August 30, 2018.http://atlasofscience.org/pharmacological-approaches-targeting-immune-cell-and-oxidative-biology-in-allergic-asthma/ ‡
Digital and other novel forms of scholarship (with electronic links displayed, if relevant)