Anderson Publishes a Study Protocol to Reduce Antimicrobial Use in Nursing Home Residents

Ruth Anderson, along with PI Susan Mitchell and UNC collaborator Laura Hanson, recently published a new article in Trials. TRAIN-AD is the first cluster randomized clinical trial testing a multicomponent
intervention to improve infection management in nursing home residents with advanced dementia:

Infections are common in nursing home (NH) residents with advanced dementia but are often managed inappropriately. Antimicrobials are extensively prescribed, but frequently with insufficient evidence to support a bacterial infection, promoting the emergence of multidrug-resistant organisms. Moreover, the benefits of antimicrobials remain unclear in these seriously ill residents for whom comfort is often the goal of care. Prior NH infection management interventions evaluated in randomized clinical trials (RCTs) did not consider patient preferences and lack evidence to support their effectiveness in ‘real-world’ practice.

TRAIN-AD is the first cluster RCT testing a multicomponent intervention to improve infection management in NH residents with advanced dementia. Its findings will provide an evidence base to support the benefit of a program addressing the critical clinical and public health problem of antimicrobial misuse in these seriously ill residents. Moreover, its hybrid efficacy-effectiveness design will inform the future conduct of cluster RCTs evaluating nonpharmacological interventions in the complex NH setting in a way that is both internally valid and adaptable to the ‘real-world’.

The article can be found here. Congratulations Dr. Anderson!